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Protonix



Protonix Drug


Pantoprazole (marketed under the brand names Protonix and Pantoloc) is a proton pump inhibitor drug used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. Initial treatment is generally of eight weeks' duration, after which another eight week course of treatment may be considered if necessary.


Pharmacology
Pantoprazole is metabolized in the liver by the cytochrome P450 system. Metabolism mainly consists of demethylation by CYP2C19 followed by sulfation. Another metabolic pathway is oxidation by CYP3A4. Pantoprazole metabolites are not thought to have any pharmacological significance

Availability
Pantoprazole was developed by Altana and is currently marketed under the brand name Protonix by Wyeth-Ayerst Laboratories, Somac by Pfizer, and as Pantoloc by Solvay Pharma. It is available by prescription in controlled-release tablets.

Other useful drug information: Atenolol | Zyrtec | Alprazolam | Mucinex | Naproxen | Oxycodone | Clonazepam

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