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Propoxyphene




Dextropropoxyphene is an analgesic in the opioid category. It is used to treat mild to moderate pain and as an antitussive. It can be used to ease pain before, during and after an operation. It is often combined with acetominophen in the preparation co-proxamol(Darvocet in the US).


It is an optical isomer of Levopropoxyphene. The racemic mixture is called Propoxyphene.

Propoxyphene Drug
Some preparations that contain dextropoxyphene include: Distalgesic and Doloxene.

The therapeutic index of dextropoxyphene is relatively small. In the UK, dextropoxyphene and co-proxamol are now discouraged from general use, and since 2004 preparations containing only dextropropoxyphene have been discontinued. This has been a somewhat controversial decision, since it has caused abusers to switch to the combined product and risk acetominophen toxicity. Australia declined to follow suit, and opted to allow pure dextropropoxyphene to remain available by prescription.

In the United States, dextropropoxyphene HCl is available as a prescription with acetaminophen in ratio anywhere from 30mg / 600mg to 60mg / 325mg, respectively. These are usually named "Darvocet," "Darvin," or "Darvon." Dextropropoxyphene is subject to some controversy: while many physicians prescribe it for a wide range of mildly to moderately painful symptoms as well as in treatment of diarrhoea, many others refuse to prescribe it, citing its highly addictive nature and limited effectiveness (some studies show it to be no more effective as a painkiller than aspirin).

In Australia, dextropropoxyphene is available on presription, both as a combined product (32.5mg dextropropoxyphene per 325mg acetaminophen) and in pure form (100mg capsules). Whilst the combined product is used by some physicians for pain management, many prefer to use codeine combination products instead. In pure form, dextropropoxyphene is commonly used to ease the withdrawl symptoms in people addiced to opioids. Being very weak in comparison to those opioids which are commonly abused, dextropropoxyphene can only act as a "partial" substitute. It does not have much effect on mental cravings, however it can be effective in alleviating physical withdrawl effects such as muscle cramps.

Darvocet overdose is commonly broken into two categories: liver toxicity (from acetaminophen poisoning) and dextropropoxyphene overdose. Many users experience toxic effects from the acetaminophen in pursuit of the endlessly-increasing dose required to achieve euphoria. They suffer acute liver toxicity, which causes severe stomach pain, nausea, and vomiting (all of which are increased by light or stimulation of the sense of sight).

Other users experience longer-term problems from consistent use of abusively high dextropropoxyphene levels. They take anywhere from 240 to 420 milligrams of dextropropoxyphene (and the acetaminophen that goes with it) in search of an increasingly elusive feeling of euphoria. These users often suffer a constantly dry mouth, decreased appetite, urinary retention and constipation. Because tolerance to dextropropoxyphene increases so quickly and because of its strong constipating effects, many people suffer a gruesome and painful rupture in the colon.

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