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Metoprolol



Metoprolol Drug
Metoprolol is a selective beta1 receptor blocker used in treatment of several diseases of the cardiovascular system. It is marketed under the brand name Lopressor by Novartis, and Toprol (in the USA), Seleken or Selokeen (elsewhere) by "Betaloc" AstraZeneca and as Corvitol by Berlin-Chemie AG. Generic brands marketed in the Australasian region include "Minax" Alphapharm, "Metrol" Arrow and "Metohexal" Hexal.


It should be noted that Lopressor refers to metoprolol tartrate, while Toprol refers to metoprolol succinate, the sustained-release formulation.

Properties:

Cardioselective
Lipophilic
Without intrinsic sympathomimetic activity (ISA)
Without membrane stabilizing activity
Short half-life must be taken at least twice daily or SR preparations
Indications:

Essential hypertension
Arrhythmias
Coronary heart disease (prevention of angina attacks)
Secondary prevention after a myocardial infarction
Low dosed treatment of some forms of heart failure (see MERIT-HF study1)
Migraine prophylaxis
Adjunct in treatment of hyperthyroidism
In the United States and most other countries, this medication is available only by prescription.

Other useful drug information: Prilosec | Fluoxetine | Isotretinoin | Naproxen | Luvox | Metoprolol | Reglan

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