Clomifene or clomifene citrate (old name clomiphene, sold as Clomid, Serophene, Milophene and many others) is a selective estrogen receptor modulator (SERM), used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome). In some countries, it is also registered for use in men.
Clomifene is a racemic mixture of two geometric isomers, enclomifene and zuclomifene.
Clomifene acts by inhibiting the action of estrogen on the gonadotrope cells in the anterior pituitary gland. "Sensing" low estrogen levels, follicle-stimulating hormone release is increased, leading to a higher rate of ovulation and hence pregnancy.
Clomifene can lead to multiple ovulation, and hence increasing the risk of twins. In comparison to purified FSH, the rate of ovarian hyperstimulation syndrome is low. There may be an increased risk of ovarian cancer, and weight gain.
As with any drug, each person's reaction can vary. Most commonly, women complain of "hormone hell" and/or hot flashes, as well as breast tenderness and headache. A slight increase in the chance of multiple births (10%) has been reported.
Ironically, thinning of the uterine lining and "hostile" cervical mucous can occur, decreasing the chance of pregnancy. As with any medication, informed decision-making is essential.
As with most ovulation-inducing drugs, there is a risk of ovarian hyperstimulation. An untrasound and physical exam should be performed prior to prescribing, to ensure there are no ovarian cysts.
Typically, blood is drawn on the 21st day of the cycle for a progesterone check
Use In Bodybuilding
Clomifene is commonly used by male anabolic steroid users to bind the estrogen receptors in their bodies, thereby blocking the effects of estrogen, ie gynecomastia. It also restores the bodies natural production of testosterone. It is commonly used as a "recovery drug" and taken toward the end of a steroid cycle.
Other useful drug information: Voltaren | Indomethacin | Lovastatin | Mirtazapine | Flonase | Diclofenac | Temazepam
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