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Aciphex



Rabeprazole is a proton pump inhibitor sold (as its sodium salt) under the brand name Aciphex and Pariet (distributed by Janssen-Ortho).


Aciphex Drug
It is used in the treatment of gastric ulcers and GERD (or heartburn). It is taken once/day along with a full glass of water (preferable 30 min before breakfast). The duration of treatment is usually 4 weeks but could be longer if the symptoms persist.

Sometimes, one may start feeling better after a few days but it is essential to complete the full course of treatment.

The active ingredient in ACIPHEX Delayed-Release Tablets is rabeprazole sodium, a substituted benzimidazole that inhibits gastric acid secretion. Rabeprazole sodium is known chemically as 2--methyl]sulfinyl] -1Hbenzimidazole sodium salt. It has an empirical formula of C18H20N3NaO3S and a molecular weight of 381.43. Rabeprazole sodium is a white to slightly yellowish-white solid. It is very soluble in water and methanol, freely soluble in ethanol, chloroform and ethyl acetate and insoluble in ether and n-hexane. The stability of rabeprazole sodium is a function of pH; it is rapidly degraded in acid media, and is more stable under alkaline conditions.

ACIPHEX is available for oral administration as delayed-release, enteric-coated tablets containing 20 mg of rabeprazole sodium. Inactive ingredients are carnauba wax, crospovidone, diacetylated monoglycerides, ethylcellulose, hydroxypropyl cellulose, hypromellose phthalate, magnesium stearate, mannitol, sodium hydroxide, sodium stearyl fumarate, talc, titanium dioxide, and yellow ferric oxide as a coloring agent.

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